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by Roncero, Carlos; Vega, Pablo; Martinez-Raga, Jose; Barral, Carmen; Basurte-Villamor, Ignacio; Rodriguez-Cintas, Laia; Mesias, Beatriz; Grau-Lopez, Lara; Casas, Miguel; Szerman, Nestor
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This article is from International Journal of Mental Health Systems , volume 8 . Abstract Background: Since provision of integrated services for patients with dual pathology or dual disorders (coexistence of an addictive disorder and other psychiatric disorders) constitutes an important challenge, this study compared the perceptions of health-care professionals with the existing, current state of specific resources for patients with dual pathology in Spain. Methods: Epidemiological,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158069
PubMed Central
by Solera, Dafne
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This article is from BMC Cancer , volume 14 . Abstract Contributing reviewers: The editors of BMC Cancer would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909450
PubMed Central
by Sandhu, Jaspal Singh; Gupta, Giniya; Shenoy, Shweta
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This article is from Asian Journal of Sports Medicine , volume 1 . Abstract Purpose: Accurate measurement or prediction of fat mass is useful in physiology, nutrition and clinical medicine. Most predictive equations currently used to assess percentage of body fat or fat mass, using simple anthropometric measurements were derived from people in western societies and they may not be appropriate for individuals with other genotypic and phenotypic characteristics. We developed equations to predict...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289169
PubMed Central
by Foote, Christopher
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This article is from BMC Research Notes , volume 7 . Abstract Contributing reviewers: The editors of BMC Research Notes would like to thank all of our reviewers who have contributed to the journal in volume 6 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895785
PubMed Central
by Sirim, Demet; Widmann, Michael; Wagner, Florian; Pleiss, Jurgen
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This article is from BMC Structural Biology , volume 10 . Abstract Background: Cytochrome P450 monooxygenases (CYPs) form a vast and diverse family of highly variable sequences. They catalyze a wide variety of oxidative reactions and are therefore of great relevance in drug development and biotechnological applications. Despite their differences in sequence and substrate specificity, the structures of CYPs are highly similar. Although being in research focus for years, factors mediating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224734
This article is from History of the Human Sciences , volume 26 . Abstract This article argues that the meaning of the word ‘autism’ experienced a radical shift in the early 1960s in Britain which was contemporaneous with a growth in epidemiological and statistical studies in child psychiatry. The first part of the article explores how ‘autism’ was used as a category to describe hallucinations and unconscious fantasy life in infants through the work of significant child psychologists and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757918
PubMed Central
by Rice, Catherine M
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This article is from BMC Genomics , volume 14 . Abstract Contributing reviewers: The editors of BMC Genomics would like to thank all our reviewers who have contributed to the journal in volume 13 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642022
PubMed Central
by Harold, Simon
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This article is from BMC Plant Biology , volume 14 . Abstract Contributing reviewers: The editors of BMC Plant Biology would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897928
PubMed Central
by Navidghasemizad, Sahar; Takala, Timo M; Alatossava, Tapani; Saris, Per EJ
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This article is from Bioengineered , volume 4 . Abstract In this study the growth of genetically modified Lactobacillus casei LAB6, overexpressing proline iminopeptidase PepI and its capacity to increase free proline was investigated during ripening of Edam cheese. The strain successfully survived 12 weeks of ripening period in cheese. The food-grade plasmid pLEB604, carrying the pepI gene, was stable, and PepI enzyme was active in LAB6 cells isolated at different stages of the ripening...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937202
PubMed Central
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This article is from United European Gastroenterology Journal , volume 1 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070603
PubMed Central
by Pafitis, Natalie
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This article is from BMC Public Health , volume 13 . Abstract Contributing reviewers: The editors of BMC Public Health would like to thank all our reviewers who have contributed to the journal in 2012.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751667
PubMed Central
by Huang, Fei; Chen, Ye-Guang
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This article is from Cell & Bioscience , volume 2 . Abstract TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer and tissue fibrosis. TGF-β signaling is tightly regulated at different levels along the pathway, and modulation of TGF-β receptor activity is a critical step for signaling regulation. This review focuses on our...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333473
PubMed Central
by Gall, Astrid; Kaye, Steve; Hue, Stephane; Bonsall, David; Rance, Richard; Baillie, Gregory J; Fidler, Sarah J; Weber, Jonathan N; McClure, Myra O; Kellam, Paul
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This article is from Retrovirology , volume 10 . Abstract Background: Dynamic changes in Human Immunodeficiency Virus 1 (HIV-1) sequence diversity and divergence are associated with immune control during primary infection and progression to AIDS. Consensus sequencing or single genome amplification sequencing of the HIV-1 envelope (env) gene, in particular the variable (V) regions, is used as a marker for HIV-1 genome diversity, but population diversity is only minimally, or semi-quantitatively...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605130
PubMed Central
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This article is from United European Gastroenterology Journal , volume 1 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070608
PubMed Central
by Rehman Malik, Abdur; Iqbal Quddusi, Ahmed; Naila,
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This article is from Pakistan Journal of Medical Sciences , volume 29 . Abstract Objective: The study was conducted to determine the etiology of seizures in neonates.Methods: This was a descriptive Cross-sectional study. This study was conducted at neonatal unit of children hospital and institute of child health Multan from June 2012 to April 2013. A total of 285 neonates who presented with seizures were enrolled for the possible causes. First line investigations including blood glucose, serum...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858915
PubMed Central
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This article is from Annals of The Royal College of Surgeons of England , volume 94 . Abstract INTRODUCTION: The preliminary results of a pyrocarbon interpositional radiocarpal implant in a small cohort of patients were reviewed. As it is currently only a limited release product, we describe to potential users early complications and negative outcomes. METHODS: Patients were assessed using pain levels, ranges of motion, grip strength, type of and time to return to work as well as pre-operative...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954246
PubMed Central
by Jackson, Chandra L; Kawachi, Ichiro; Redline, Susan; Juon, Hee-Soon; Hu, Frank B
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This article is from BMC Public Health , volume 14 . Abstract Background: Although short sleep is associated with an increased risk of morbidity as well as mortality and has been shown to vary by industry of employment and occupation, little is known about the relationship between work and sleep among Asian Americans. Methods: Using a nationally representative sample of US adults (n = 125,610) in the National Health Interview Survey from 2004–2011, we estimated prevalence ratios for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057824
PubMed Central
by Schneider, Armin; Rogalewski, Andreas; Wafzig, Oliver; Kirsch, Friederike; Gretz, Norbert; Kruger, Carola; Diederich, Kai; Pitzer, Claudia; Laage, Rico; Plaas, Christian; Vogt, Gerhard; Minnerup, Jens; Schabitz, Wolf-Rudiger
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This article is from Experimental & Translational Stroke Medicine , volume 6 . Abstract Background and purpose: Both the immobilization of the unaffected arm combined with physical therapy (forced arm use, FAU) and voluntary exercise (VE) as model for enriched environment are promising approaches to enhance recovery after stroke. The genomic mechanisms involved in long-term plasticity changes after different means of rehabilitative training post-stroke are largely unexplored. The present...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937028
PubMed Central
by Beecham, Gary W.; Hamilton, Kara; Naj, Adam C.; Martin, Eden R.; Huentelman, Matt; Myers, Amanda J.; Corneveaux, Jason J.; Hardy, John; Vonsattel, Jean-Paul; Younkin, Steven G.; Bennett, David A.; De Jager, Philip L.; Larson, Eric B.; Crane, Paul K.; Kamboh, M. Ilyas; Kofler, Julia K.; Mash, Deborah C.; Duque, Linda; Gilbert, John R.; Gwirtsman, Harry; Buxbaum, Joseph D.; Kramer, Patricia; Dickson, Dennis W.; Farrer, Lindsay A.; Frosch, Matthew P.; Ghetti, Bernardino; Haines, Jonathan L.;...
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This article is from PLoS Genetics , volume 10 . Abstract Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association study and analysis of known genetic risk loci for AD dementia using neuropathologic data from 4,914 brain autopsies. Neuropathologic data were used to define clinico-pathologic AD dementia or controls, assess core...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154667
PubMed Central
by Harris, Philippa K
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This article is from BMC Microbiology , volume 13 . Abstract Contributing reviewers: The editors of BMC Microbiology would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576289
PubMed Central
by Turner, Leslie M.; White, Michael A.; Tautz, Diethard; Payseur, Bret A.
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This article is from PLoS Genetics , volume 10 . Abstract Hybrid dysfunction, a common feature of reproductive barriers between species, is often caused by negative epistasis between loci (“Dobzhansky-Muller incompatibilities”). The nature and complexity of hybrid incompatibilities remain poorly understood because identifying interacting loci that affect complex phenotypes is difficult. With subspecies in the early stages of speciation, an array of genetic tools, and detailed knowledge of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930512
PubMed Central
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This article is from Virology Journal , volume 11 . Abstract : The editors of Virology Journal would like to thank all our reviewers who have contributed to the journal in Volume 10 (2013). The success of any scientific journal depends on an effective and strict peer review process and Virology Journal could not operate without your contribution. We are grateful to the large number of reviewers (1026 to be exact!), who have done a great job in not only lifting the quality of the journal’s...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898089
PubMed Central
by Golshiri, Ali; Mokhtaree, Mohammad Reza; Shabani, Ziba; Tabatabaee, Sayed Taghi; Rahnama, Amir; Moradi, Mohammad; Sayadi, Ahamad Reza; Faezi, Hadi
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This article is from Addiction & Health , volume 1 . Abstract Background:: To determine the effect of opium smoking cessation on the frequency and type of microorganisms in the nasopharynx of opium smokers. Methods:: This was a cross-sectional study performed in psychology and ENT department of Moradi Hospital of Rafsanjan University of Medical Sciences in 2008 (Kerman, Iran). Nasopharyngeal cultures were taken from 50 opium smokers before and 2 to 3 months after cessation of opium smoking....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905491
PubMed Central
by Tuteja, Amit; Siddiqui, Abu Baker; Madan, Kaushal; Goyal, Rohit; Shalimar,; Sreenivas, Vishnubhatla; Kaur, Navkiran; Panda, Subrat K.; Narayanasamy, Krishnamoorthy; Subodh, Swati; Acharya, Subrat K.
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This article is from PLoS ONE , volume 9 . Abstract Aims: The aim of this study was to investigate the genomic mutations in the circulating Hepatitis B virus strains causing infection in the Indian population. Further, we wanted to analyze the biological significance of these mutations in HBV mediated disease. Methods: 222 HBsAg positive patients were enrolled in the study. The genotype and mutation profile was determined for the infecting HBV isolate by sequencing overlapping fragments. These...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956465
PubMed Central
by Choi, Sang-Ho; Hong, Sang-Bum; Hong, Hyo-Lim; Kim, Sung-Han; Huh, Jin Won; Sung, Heungsup; Lee, Sang-Oh; Kim, Mi-Na; Jeong, Jin-Yong; Lim, Chae-Man; Kim, Yang Soo; Woo, Jun Hee; Koh, Younsuck
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This article is from PLoS ONE , volume 9 . Abstract Background: The usefulness of bronchoalveolar lavage (BAL) fluid cellular analysis in pneumonia has not been adequately evaluated. This study investigated the ability of cellular analysis of BAL fluid to differentially diagnose bacterial pneumonia from viral pneumonia in adult patients who are admitted to intensive care unit. Methods: BAL fluid cellular analysis was evaluated in 47 adult patients who underwent bronchoscopic BAL following less...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019586
PubMed Central
by Xiong, Zhi-Qiang; Wang, Jian-Feng; Hao, Yu-You; Wang, Yong
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This article is from Marine Drugs , volume 11 . Abstract Marine microbial natural products (MMNPs) have attracted increasing attention from microbiologists, taxonomists, ecologists, agronomists, chemists and evolutionary biologists during the last few decades. Numerous studies have indicated that diverse marine microbes appear to have the capacity to produce an impressive array of MMNPs exhibiting a wide variety of biological activities such as antimicrobial, anti-tumor, anti-inflammatory and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705366
PubMed Central
by Chandler, Clare IR; DiLiberto, Deborah; Nayiga, Susan; Taaka, Lilian; Nabirye, Christine; Kayendeke, Miriam; Hutchinson, Eleanor; Kizito, James; Maiteki-Sebuguzi, Catherine; Kamya, Moses R; Staedke, Sarah G
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This article is from Implementation Science : IS , volume 8 . Abstract Background: Despite significant investments into health improvement programmes in Uganda, health indicators and access to healthcare remain poor across the country. The PRIME trial aims to evaluate the impact of a complex intervention delivered in public health centres on health outcomes of children and management of malaria in rural Uganda. The intervention consists of four components: Health Centre Management; Fever Case...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849653
PubMed Central
by Morawska, Magdalena
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This article is from BMC Family Practice , volume 15 . Abstract Contributing reviewers: The editors of BMC Family Practice would like to thank all of our reviewers who have contributed to the journal in Volume 14 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121002
PubMed Central
by Giannella-Neto, Daniel; de Brito Gomes, Marilia; Abel, Lucy
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This article is from Diabetology & Metabolic Syndrome , volume 5 . Abstract Contributing reviewers: The Editors of Diabetology and Metabolic Syndrome would like to thank all reviewers, both external and Editorial Board Members, who have contributed to the journal since its inception, and whose valuable support continues to be essential to the success of the journal.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605392
PubMed Central
by Dunlop, Rebecca A.; Noad, Michael J.; Cato, Douglas H.; Kniest, Eric; Miller, Patrick J. O.; Smith, Joshua N.; Stokes, M. Dale
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This article is from The Journal of Experimental Biology , volume 216 . Abstract The behavioural response study (BRS) is an experimental design used by field biologists to determine the function and/or behavioural effects of conspecific, heterospecific or anthropogenic stimuli. When carrying out these studies in marine mammals it is difficult to make basic observations and achieve sufficient samples sizes because of the high cost and logistical difficulties. Rarely are other factors such as...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705903
PubMed Central
by Rowles, Thomas A
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This article is from BMC Surgery , volume 14 . Abstract Contributing reviewers: The editors of BMC Surgery would like to thank all our reviewers who have contributed their time to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893518
PubMed Central
by Kuiper, Jan Willem; Groeneveld, AB Johan; Haitsma, Jack J; Smeding, Lonneke; Begieneman, Mark PV; Jothy, Serge; Vaschetto, Rosanna; Plotz, Frans B
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This article is from BMC Nephrology , volume 15 . Abstract Background: Intratracheal aspiration and sepsis are leading causes of acute lung injury that frequently necessitate mechanical ventilation (MV), which may aggravate lung injury thereby potentially increasing the risk of acute kidney injury (AKI). We compared the effects of ventilation strategies and underlying conditions on the development of AKI. Methods: Spraque Dawley rats were challenged by intratracheal acid instillation or 24 h...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119441
PubMed Central
by Hommel, Marcel
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This article is from Malaria Journal , volume 13 . Abstract Contributing reviewers: Malaria Journal would like to thank all reviewers who have contributed to the journal in 2013.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917501
PubMed Central
by Durrant, Douglas M.; Robinette, Michelle L.; Klein, Robyn S.
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This article is from The Journal of Experimental Medicine , volume 210 . Abstract IL-1R1 signaling drives T cell activation in the CNS via effects on DC activation.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600909
PubMed Central
by Hauser, Thomas; Adam, Jennifer; Schulz, Henry
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This article is from Theoretical Biology & Medical Modelling , volume 11 . Abstract Background: The purpose of this study was the comparison of the calculated (MLSSC) and experimental power (MLSSE) in maximal lactate steady-state (MLSS) during cycling. Methods: 13 male subjects (24.2 ± 4.76 years, 72.9 ± 6.9 kg, 178.5 ± 5.9 cm, V˙O2max: 60.4 ± 8.6 ml min−1 kg−1, V˙Lamax: 0.9 ± 0.19 mmol l-1 s-1) performed a ramp-test for determining the V˙O2max and a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052616
PubMed Central
by Hashemi, Somayeh; Seddigh, Sedighe; Tehrani, Fahimeh Ramezani; Khansari, Seyed Mehdi Hasanzadeh; Khodakarami, Nahid
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This article is from Journal of Reproduction & Infertility , volume 14 . Abstract Background: Sexual practices as an important aspect of reproductive health have many physical and psychological effects on people's lives, there is limited evidence on such practices and their pattern among Iranian women. Hence we aimed to determine different types of sexual practices among 19–45 year old married Iranian women. Methods: This cross-sectional study was conducted among 200 married women, aged...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719361
PubMed Central
by Wang, Juan; Duan, Erhong; Zhou, Erpeng; Yao, Qingguo; Zhang, Wenna
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 67 . Abstract In the title compound, C14H19I, the cyclo­hexane ring adopts a chair conformation and the substituents are in equatorial sites. The dihedral angle between the mean planes of the cyclo­hexane and benzene rings is 67.23 (13)°.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120325
PubMed Central
by Anthelme, Fabien; Cavieres, Lohengrin A.; Dangles, Olivier
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This article is from Frontiers in Plant Science , volume 5 . Abstract While there is a large consensus that plant–plant interactions are a crucial component of the response of plant communities to the effects of climate change, available data remain scarce, particularly in alpine systems. This represents an important obstacle to making consistent predictions about the future of plant communities. Here, we review current knowledge on the effects of climate change on facilitation among alpine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130109
PubMed Central
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This article is from ZooKeys . Abstract AbstractThe first overview on the Auchenorrhyncha fauna of peat bogs of the Austrian Bohemian Forest is presented. Seven oligotrophic peat bog sites were studied in 2011 by suction sampler (“G-Vac”) and 93 Auchenorrhyncha species (with 7465 adult specimens) were recorded. Eleven species (about 18 % of the individuals) are tyrphobiontic or tyrphophilous. The relative species abundance plot is not very steep; the six most abundant species represent...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764520
PubMed Central
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This article is from Therapeutics and Clinical Risk Management , volume 10 . Abstract Lymphangioleiomyomatosis (LAM) is an uncommon disease presented as diffuse thin-walled cystic changes in the lung. The main differential diagnoses include pulmonary Langerhans’ histiocytosis (PLCH), Birt-Hogg-Dubé syndrome (BHD), lymphoid interstitial pneumonia (LIP), and amyloidosis. A combination of clinical, radiological, and pathological approaches as well as genetic testing will clarify the diagnosis...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149398
PubMed Central
by Guarda-Nardini, Luca; Manfredini, Daniele; Olivo, Marco; Ferronato, Giuseppe
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This article is from Journal of Oral & Maxillofacial Research , volume 5 . Abstract Background: The literature on total alloplastic temporomandibular joint (TMJ) reconstructions is encouraging, and studies on total alloplastic TMJ replacements outcomes showed acceptable improvements in terms of both pain levels and jaw function. Nevertheless, some adverse events, such as heterotopic bone formation around the implanted prosthesis, may occur. In consideration of that, the present manuscript...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007372
PubMed Central
by Gonzalez-Aguilera, Cristina; Palladino, Francesca; Askjaer, Peter
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This article is from Briefings in Functional Genomics , volume 13 . Abstract The precise developmental map of the Caenorhabditis elegans cell lineage, as well as a complete genome sequence and feasibility of genetic manipulation make this nematode species highly attractive to study the role of epigenetics during development. Genetic dissection of phenotypical traits, such as formation of egg-laying organs or starvation-resistant dauer larvae, has illustrated how chromatin modifiers may regulate...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031453
PubMed Central
by Mendonca, Janet; Sharma, Anup; Kim, Hae-Soo; Hammers, Hans; Meeker, Alan; De Marzo, Angelo; Carducci, Michael; Kauffman, Michael; Shacham, Sharon; Kachhap, Sushant
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This article is from Oncotarget , volume 5 . Abstract Mislocalization of proteins is a common feature of cancer cells. Since localization of proteins is tightly linked to its function, cancer cells can inactivate function of a tumor suppressor protein through mislocalization. The nuclear exportin CRM1/XPO 1 is upregulated in many cancers. Targeting XPO 1 can lead to nuclear retention of cargo proteins such as p53, Foxo, and BRCA1 leading to cell cycle arrest and apoptosis. We demonstrate that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171616
PubMed Central
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043535
PubMed Central
by Nilsen, Per; Roback, Kerstin; Brostrom, Anders; Ellstrom, Per-Erik
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This article is from Implementation Science : IS , volume 7 . Abstract Background: Social cognitive theories on behaviour change are increasingly being used to understand and predict healthcare professionals’ intentions and clinical behaviours. Although these theories offer important insights into how new behaviours are initiated, they provide an incomplete account of how changes in clinical practice occur by failing to consider the role of cue-contingent habits. This article contributes to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464791
PubMed Central
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This article is from Current Therapeutic Research, Clinical and Experimental , volume 76 . Abstract Background: Cactus (Opuntia ficus-indica) fiber was shown to promote weight loss in a 3-month clinical investigation. As demonstrated by in vitro studies, cactus fiber binds to dietary fat and its use results in reduced absorption, which in turn leads to reduced energy absorption and ultimately the reduction of body weight. Objective: The objective of our study was to elucidate the dietary fat...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109417
PubMed Central
by Zhou, Ting; Lu, Saihua; Liu, Xiufeng; Zhang, Ye; Xu, Feng
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This article is from Patient preference and adherence , volume 7 . Abstract Human serum albumin (HSA) is an ideal natural colloid that has been widely used in clinical practice for supplemental albumin or as a plasma substitute during therapeutic plasma exchanges to redress hypoproteinemia. However, a paucity of well-designed clinical trials, a lack of a clear cut survival benefit, and frequent case reports of adverse drug reaction (ADR) make the use of HSA controversial. This study aims to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849079
PubMed Central
by Zhang, Jing-Chao; Sun, Jun; Zhang, Juan; Liu, Guang-Lin; Guo, Cheng
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 69 . Abstract In the title compound, C10H12O3, the dihedral angle between the benzene ring and the meth­oxy­methyl side chain is 9.7 (2)°. The O atom of the aldehyde group and the C atom of the meth­oxy group deviate from the plane of the ring by 0.039 (3) and 0.338 (4) Å, respectively. The only inter­molecular inter­actions are very weak C—H⋯π inter­actions.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588244
PubMed Central
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This article is from Pakistan Journal of Medical Sciences , volume 30 . Abstract Objective: To assess the degree of applicability of bone age calculated by Greulich & Pyle Atlas in estimation of chronological age for therapeutic and medico legal purposes.Methods: Two Hundred and Twenty children (139 males, 81 females) between ages of 56 and 113 months (4.5 to 9.5 years) were randomly selected from 4 primary schools of Shireen Jinnah & Clifton, Karachi. Digital images of hand and wrist...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999020
PubMed Central
by Al-Halabi, Becher; Marwan, Yousef; Hasan, Mohammad; Alkhadhari, Sulaiman
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This article is from Advances in Medical Education and Practice , volume 5 . Abstract Background: Research is the foundation of scientific advancement and improvement in quality of health care, which ensures the good health of the community. The aim of this study is to explore experiences, attitudes, and barriers of medical students in Kuwait University (KU) in regards to extracurricular research. Methods: A questionnaire about extracurricular research activities (ie, any research activity that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010614
PubMed Central
by Waldmann, Jost; Gerken, Jan; Hankeln, Wolfgang; Schweer, Timmy; Glockner, Frank Oliver
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This article is from BMC Research Notes , volume 7 . Abstract Background: Advances in sequencing technologies challenge the efficient importing and validation of FASTA formatted sequence data which is still a prerequisite for most bioinformatic tools and pipelines. Comparative analysis of commonly used Bio*-frameworks (BioPerl, BioJava and Biopython) shows that their scalability and accuracy is hampered. Findings: FastaValidator represents a platform-independent, standardized, light-weight...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094456
PubMed Central
by Ibarra, Jose Antonio; Perez-Rueda, Ernesto; Carroll, Ronan K; Shaw, Lindsey N
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This article is from BMC Genomics , volume 14 . Abstract Background: Staphylococcus aureus is a widely distributed human pathogen capable of infecting almost every ecological niche of the host. As a result, it is responsible for causing many different diseases. S. aureus has a vast array of virulence determinants whose expression is modulated by an intricate regulatory network, where transcriptional factors (TFs) are the primary elements. In this work, using diverse sequence analysis, we...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616918
PubMed Central
by Biesemeier, Frank; Geiseler, Gertraud; Harms, Klaus; Muller, Ulrich
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 70 . Abstract In, K+·SO3–p-C6H4–N3−, the conformation angle of the azido group with respect to the benzene ring is 19.1 (3)°, so that the anion is chiral within the crystal structure. In addition, the crystal structure is also chiral (Sohncke space group). The potassium ion is coordinated by three closer O atoms from three different sulfonyl groups [K⋯O 2.6486 (17) to 2.7787 (17) Å],...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158513
PubMed Central
by Neuhofer, Angelika; Zeyda, Maximilian; Mascher, Daniel; Itariu, Bianca K.; Murano, Incoronata; Leitner, Lukas; Hochbrugger, Eva E.; Fraisl, Peter; Cinti, Saverio; Serhan, Charles N.; Stulnig, Thomas M.
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This article is from Diabetes , volume 62 . Abstract Obesity-induced chronic low-grade inflammation originates from adipose tissue and is crucial for obesity-driven metabolic deterioration, including insulin resistance and type 2 diabetes. Chronic inflammation may be a consequence of a failure to actively resolve inflammation and could result from a lack of local specialized proresolving lipid mediators (SPMs), such as resolvins and protectins, which derive from the n-3 polyunsaturated fatty...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661630
PubMed Central
by Filips, Dennis; Logsetty, Sarvesh; Tan, Jonathan; Atkinson, Ian; Mottet, Kelly
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This article is from Prehospital Emergency Care , volume 17 . Abstract Objective.Severe hemorrhage is a leading cause of death and difficult to control even by trained medical personnel. Current interventions have significant limitations in the prehospital setting; therefore, a need exists for a new and effective treatment. iTraumaCare has designed a temporary wound closure device, the iTClamp, which controls external hemorrhage from open wounds within compressible zones. The device...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786550
PubMed Central
by Insalaco, A; Messia, V; Pardeo, M; Nicolai, R; Bracaglia, C; De Benedetti, F
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This article is from Pediatric Rheumatology Online Journal , volume 11 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044283
PubMed Central
by Tabata, Ryo; Sawa, Shinichiro
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This article is from Frontiers in Plant Science , volume 5 . Abstract In the past decade, small secreted peptides have proven to be essential for various aspects of plant growth and development, including the maintenance of certain stem cell populations. Most small secreted peptides identified in plants to date are recognized by membrane-localized receptor kinases, the largest family of receptor proteins in the plant genome. This peptide-receptor interaction is essential for initiating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082320
PubMed Central
by Hoffman, Donald D.; Prakash, Chetan
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This article is from Frontiers in Psychology , volume 5 . Abstract Current models of visual perception typically assume that human vision estimates true properties of physical objects, properties that exist even if unperceived. However, recent studies of perceptual evolution, using evolutionary games and genetic algorithms, reveal that natural selection often drives true perceptions to extinction when they compete with perceptions tuned to fitness rather than truth: Perception guides adaptive...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060643
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This article is from BMC Systems Biology , volume 8 . Abstract Background: Living cells are realized by complex gene expression programs that are moderated by regulatory proteins called transcription factors (TFs). The TFs control the differential expression of target genes in the context of transcriptional regulatory networks (TRNs), either individually or in groups. Deciphering the mechanisms of how the TFs control the expression of target genes is a challenging task, especially when multiple...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080427
PubMed Central
by Rendleman, Justin; Antipin, Yevgeniy; Reva, Boris; Adaniel, Christina; Przybylo, Jennifer A.; Dutra-Clarke, Ana; Hansen, Nichole; Heguy, Adriana; Huberman, Kety; Borsu, Laetitia; Paltiel, Ora; Ben-Yehuda, Dina; Brown, Jennifer R.; Freedman, Arnold S.; Sander, Chris; Zelenetz, Andrew; Klein, Robert J.; Shao, Yongzhao; Lacher, Mortimer; Vijai, Joseph; Offit, Kenneth; Kirchhoff, Tomas
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This article is from PLoS ONE , volume 9 . Abstract Molecular and genetic evidence suggests that DNA repair pathways may contribute to lymphoma susceptibility. Several studies have examined the association of DNA repair genes with lymphoma risk, but the findings from these reports have been inconsistent. Here we provide the results of a focused analysis of genetic variation in DNA repair genes and their association with the risk of non-Hodgkin's lymphoma (NHL). With a population of 1,297 NHL...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092067
PubMed Central
by Gracia-Paez, Jorge Isaac; Ferraz, Juliana Rosa; Franca E Silva, Ivan Avelino; Rossi, Flavia; Levin, Anna Sara; Costa, Silvia Figueiredo
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This article is from Revista do Instituto de Medicina Tropical de São Paulo , volume 55 . Abstract SUMMARY: Stenotrophomonas maltophilia contains a novel chromosomally-encoded qnr gene named Smqnr that contributes to low intrinsic resistance to quinolone. We described Smqnr in 13 clinical isolates of S. maltophilia from two Brazilian hospitals, over a 2-year period. The strains were identified by API 20 NE (bioMérieux, France). Susceptibility by microdilution method to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105090
PubMed Central
by Pathaichindachote, Wanwarang; Rungrod, Amporn; Audtho, Mongkon; Soonsanga, Sumarin; Krittanai, Chartchai; Promdonkoy, Boonhiang
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This article is from BMB reports , volume 46 . Abstract Cyt2Aa2 is a mosquito larvicidal and cytolytic toxin produced by Bacillus thuringiensis subsp. darmstadiensis. The toxin becomes inactive when isoleucine at position 150 was replaced by alanine. To investigate the functional role of this position, Ile150 was substituted with Leu, Phe, Glu and Lys. All mutant proteins were produced at high level, solubilized in carbonate buffer and yielded protease activated product similar to those of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133872
PubMed Central
by Xu, Jiansong; Calhoun, Vince D.; Pearlson, Godfrey D.; Potenza, Marc N.
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This article is from PLoS ONE , volume 9 . Abstract Background: Functional magnetic resonance imaging (fMRI) studies indicate that the brain organizes its activity into multiple functional networks (FNs) during either resting condition or task-performance. However, the functions of these FNs are not fully understood yet. Methodology/Principal Findings: To investigate the operation of these FNs, spatial independent component analysis (sICA) was used to extract FNs from fMRI data acquired from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909055
PubMed Central
by Salimi, Vahid; Tavakoli-Yaraki, Masoumeh; Mahmoodi, Mahmood; Shahabi, Shahram; Gharagozlou, Mohammad Javad; Shokri, Fazel; Mokhtari-Azad, Talat
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This article is from Iranian Red Crescent Medical Journal , volume 15 . Abstract Background: Oncolytic viruses have become of noticeable interest as a novel biological approach for selectively infecting cancer cells and triggering apoptosis in a number of malignant cells. Many researches are devoted to characterize more viruses with oncolytic properties. Objectives: Evidences on the oncolytic feature of respiratory syncytial virus (RSV) are conflicting; therefore, this study was designed to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589781
PubMed Central
by Sia, Irene G; Buckwalter, Seanne P; Doerr, Kelly A; Lugos, Sonia; Kramer, Rebecca; Orillaza-Chi, Ruth; Quelapio, Maria Imelda; Tupasi, Thelma E; Wengenack, Nancy L
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This article is from BMC Infectious Diseases , volume 13 . Abstract Background: The Philippines has an extremely high rate of tuberculosis but little is known about M. tuberculosis genotypes and transmission dynamics in this country. The aim of this study was to determine the proportion of household contacts who develop active TB due to direct transmission from an index case in that household. Methods: Mycobacterium tuberculosis isolates from household contacts of tuberculosis patients in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028849
PubMed Central
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This article is from Bioessays , volume 35 . Abstract The ABO histo-blood group, first discovered over a century ago, is found not only in humans but also in many other primate species, with the same genetic variants maintained for at least 20 million years. Polymorphisms in ABO have been associated with susceptibility to a large number of human diseases, from gastric cancers to immune or artery diseases, but the adaptive phenotypes to which the polymorphism contributes remain unclear. We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034584
PubMed Central
by Rhodes, Marjorie; Brandone, Amanda C.
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This article is from Frontiers in Psychology , volume 5 . Abstract Understanding observable behavior by considering mental representations is central to social cognition. Research reveals quite different developmental trajectories for this ability depending on whether tasks assess implicit or explicit theory of mind (ToM). Yet, how to define implicit vs. explicit ToM, the tasks that elicit each, and the types of behavior that each can support, have remained unclear. The present study (n = 47)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972464
PubMed Central
by Obradovic, Zarema; Obradovic, Amina
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This article is from Materia Socio-Medica , volume 25 . Abstract Conflict of interest: none declared.Introduction: Travellers from Bosnia and Herzegovina (B&H) travel to different world countries. The awareness of people is changing every day and nowadays travellers seek advices related to their travel and destination more often than before. In the previous years, travellers came to Travel Clinics almost only to get the vaccines which were obligatory for entry into a country. In B&H...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769084
PubMed Central
by Phatak, Prajakta; Khanagavi, Jagadish; Aronow, Wilbert S.; Puri, Sonam; Yusuf, Yasmin; Puccio, Carmelo
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This article is from F1000Research , volume 3 . Abstract Introduction: Pericardial synovial sarcoma is an extremely rare tumor with poor prognosis. Timely diagnosis and aggressive multimodal management improves patient outcome. We present our experience of diagnosis and management of a young patient with monophasic synovial sarcoma arising from pericardium.Case: A 27-year-old man presented with dyspnea and cough of three weeks duration. Examination revealed sinus tachycardia, distant heart...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954165
PubMed Central
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This article is from Microbial Cell Factories , volume 11 . Abstract Background: TliA is a thermostable lipase secreted by the type 1 secretion system (T1SS) of Pseudomonas fluorescens. The secretion is promoted by its secretion/chaperone domain located near the C-terminus, which is composed mainly of four Repeat-in-Toxin (RTX) repeats. In order to identify the minimal region of TliA responsible for its secretion, five different copies of the secretion/chaperone domain, each involving truncated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430570
PubMed Central
by Belouzard, Sandrine; Millet, Jean K.; Licitra, Beth N.; Whittaker, Gary R.
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This article is from Viruses , volume 4 . Abstract Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm. To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with the host cell membrane. The spike glycoprotein (S) mediates virus entry and is a primary determinant of cell tropism and pathogenesis. It is classified as a class I fusion protein, and is responsible for binding to the receptor on the host cell as well as...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397359
PubMed Central
by Majithia, Deesha A
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This article is from BMC Psychiatry , volume 13 . Abstract Contributing reviewers: The editors of BMC Psychiatry would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632490
PubMed Central
by Nagaraj, Anil Kumar Mysore
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This article is from Indian Journal of Psychiatry , volume 55 . Abstract Sex is a mysterious phenomenon, which has puzzled even great sages. Human beings have researched and mastered the biology of sex. But that is not all. Sex needs to be understood from the spiritual perspective too. The vision of Osho is an enlightening experience in this regard. Out of the thousands of lectures, five lectures on sex made Osho most notorious. Born into a Jain family of Madhya Pradesh, Rajneesh, who later...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705694
PubMed Central
by Curths, Christoph; Wichmann, Judy; Dunker, Sarah; Windt, Horst; Hoymann, Heinz-Gerd; Lauenstein, Hans D.; Hohlfeld, Jens; Becker, Tamara; Kaup, Franz-Josef; Braun, Armin; Knauf, Sascha
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This article is from Clinical Science (London, England : 1979) , volume 126 . Abstract Animal models with a high predictive value for human trials are needed to develop novel human-specific therapeutics for respiratory diseases. The aim of the present study was to examine lung-function parameters in marmoset monkeys (Callithrix jacchus) that can be used to detect pharmacologically or provocation-induced AHR (airway hyper-responsiveness). Therefore a custom-made lung-function device that allows...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793853
PubMed Central
by Aykut, A; Onay, H; Sagol, S; Gunduz, C; Ozkinay, F; Cogulu, O
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This article is from Balkan Journal of Medical Genetics : BJMG , volume 16 . Abstract In this study, we assessed the feasibility of fetal RhD genotyping by analysis of cell-free fetal DNA(cffDNA) extracted from plasma samples of Rhesus (Rh) D-negative pregnant women by using real-time polymerase chain reaction (PCR). Fetal genotyping was performed on 30 RhD-negative women between 9 and 39 weeks of gestation who were referred to us for invasive testing [amniocentesis/chorionic villi sampling...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001413