Drug discovery and development has a long history since the early days of human civilization. In ancient times, drugs were used for physical remedies and also associated with religious and spiritual healing. The early drugs or folk medicines were derived mainly from plant and supplemented by animal products. These drugs were most probably discovered through a combination of trial and error experiments and observation of human and animal reactions as a result of these products
Topics: Drug discovery, animals.
Will digitize
Topics: Ether, Ethyl, Anesthetics, Inhalation, Drug Discovery
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xii, 564 p. : 27 cm
Topics: Pharmacology, Experimental, Drug Discovery, Drug Evaluation
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xv, 460 p. : 27 cm
Topics: Drugs -- Design, Drug Design, Drug Discovery
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xxi, 256 p. : 26 cm
Topics: Pharmaceutical biotechnology, Technology, Pharmaceutical, Biotechnology, Drug Discovery
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Oct 23, 2017
10/17
by
iaset
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Mastitis, a disease in dairy cattle characterized by inflammation due, but not necessarily limited, to microbial infection in the mammary gland. Mastitis leads to loss in terms of reduction in milk, milk discards, early culling, increasing labour cost and veterinary services. The mammary tissue damage decreases the number and the activity of epithelial cells, caused by bacterial factors and host immune system through necrosis or apoptosis, which can be differentiated by the changes in...
Topic: Mastitis – in-Silico – Computer Aided Drug Discovery
Description: Note on the expenses and possible faculty to be involved in a collaborative study of Conotoxins and Conus snails. Accession Number: MS-003_2_2_8_3_P_0010 Collection: Series:MS-003 Sub-Series: 2 Container 1: 2 Container 2: 8 Source: 3 Repository: KS Krishnan papers Dimensions: 21x29.7cm Extent: 1p Location: Unknown Access: Handwritten note Format: Ink on Paper
Topics: Conotoxin, Conus, NCBS, Drug discovery, CDRI, ICGEB
Description: Proposal to DBT for sequencing of cDNAs from the venom ducts of Indian Conus sp to support the ongoing vigorous research on conotoxins, testing the new sequencing facilities and technology and establishing a framework for research on non-model organisms for potential commercial and therapeutic interests. Deep sequencing the cone snail venom ducts was pitched to identify genes of active peptides of therapeutic and industrial interest. Accession Number: MS-003_2_2_8_5_0002-0022...
Topics: Conus, Conotoxin, Sequencing, Venom duct, Drug discovery, Genetics
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Oct 9, 2021
10/21
by
Zanders, Edward D
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xvii, 397 p. :
Topics: Drug development -- Terminology, Pharmaceutical industry -- Terminology, Drug Discovery
I am Pankaj Oudhia working independently as researcher and documenting Traditional Medicinal Knowledge about Herbs and Insects in India. Presently my work is focused on Medicinal Rice of Asia.
Topics: Traditional Healing, Biodiversity Driven Drug Discovery, Medicinal Rice
Description: K.S. Krishnan seeks permission to collect Conus sp snails samples from fishermenʼs trash of common indigenous snails for assessment of abundance and availability for the multi-investigator project being led by him and others. The request letter clearly states that though photographic evidence would be required to do the same in marine park areas, collection of samples will not be from marine park areas but novel areas, i.e., other than the already notified sites. Accession Number:...
Topics: Conus, DBT, Indigenous species, India, Conotoxin, Drug discovery
Description: Handwritten observations and notes on fate of Drosophila melanogaster on being subjected to different types of cone snail toxins to test their potency possibly. Accession Number: MS-003_1_3_3_3_0034-0042 Collection: Series:MS-003 Sub-Series: 1 Container 1: 3 Container 2: 3 Source: 3 Repository: KS Krishnan papers Dimensions: 21x29.7cm Extent: 9p Location: Unknown Access: Handwritten note Format: Ink on paper
Topics: Conotoxin, Drosophila melanogaster, Toxicity, Drug discovery, Mutant, Conus
Description: Achievements of the project on studying peptides from Indian Conus sp snail toxins and justification for an extension of the same to keep the jobs associated with it secure until new funding or projects materialise to phase into. Accession Number: MS-003_2_2_8_4_P_0070 Collection: Series:MS-003 Sub-Series: 2 Container 1: 2 Container 2: 8 Source: 4 Repository: KS Krishnan papers Dimensions: 21x29.7cm Extent: 1p Location: Unknown Access: Note Format: Computer print
Topics: Conus, DBT, Drug discovery, Pharmacology, Peptides, Therapeutic value
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a xxv, 322 p. : 24 cm
Topics: Drug development, Drug Discovery, Biosensing Techniques, Drug Design
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Nov 9, 2021
11/21
by
Kn?blein, J?rg
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1 online resource (778 pages)
Topics: Biopharmaceutics, Drugs -- Testing -- Research, Biological Products, Drug Discovery -- methods
Diabetes mellitus is an autoimmune disorder which causes impairment in the insulin secretion or resistance. The prevalence of Diabetes is increasing day by day worldwide, also this metabolic disorder diseases is associated with high risk of cardiac problem, obesity and many other diseases. Although, there are different medications and treatments are available but still they have proven to be ineffective and associated with severe adverse effects for long term. Therapeutic compounds based on...
Topics: Diabetes, Rad-GTP ase, herbal phytochemical and Drug discovery
Description: Highlights the need for research on marine biotechnology, key areas for focus and the activities of several pre-existing institutes in India. NIMB proposes to focus on business development, research and development and setting up national facilities under it. Accession Number: MS-003_2_6_11_2_0008-0014 Collection: Series:MS-003 Sub-Series: 2 Container 1: 6 Container 2: 11 Source: 2 Repository: KS Krishnan papers Dimensions: 21x29.7cm Extent: 7p Location: "Goa, India"...
Topics: Marine Biotechnology, Drug discovery, India, National Institute for Marine Biotechnology
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Mouse models are irreplaceable tools for the study of carcinogenesis and the availability of rodent models have enabled rational screening of drugs. Hematological malignancies have been extensively studied in mouse models and broad range of lymphoid neoplasms has been reported in laboratory mice, occurring either spontaneously or after induction with radiation, chemicals or infection of newborn mice with leukemogenic viruses. Lymphomas are tumors that generally respond well to traditional...
Topics: Daltons lymphoma, T-cell lymphomas, Anti-cancer, Cancer, Drug discovery
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Mar 17, 2021
03/21
by
Ray Truant (RayTruant)
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This is a 3D model of the huntingtin N17 peptide, the first 17 amino acids of the huntingtin protein, the protein that causes Huntington's disease when mutated. My lab has shown since 2008 that this is a target region for HD drug discovery, which culminated in a new drug lead published in 2018. The peptide seqeunce is an alpha-helix, sequence: MATLEKLMKAFESLKSFQ... The two serines are hypo-phosphorylated in Huntington's disease, but can be restored by small molecule drug leads. References (Open...
Topics: protein structure, drug discovery, Biology, Huntington's disease, stl, thingiverse, protein
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DrugPedia: A Wikipedia for Drug discovery dumped with WikiTeam tools.
Topics: wiki, wikiteam, MediaWiki, DrugPedia: A Wikipedia for Drug discovery, crddosddnet_drugpedia
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Mar 14, 2022
03/22
by
Raviña Rubira, Enrique
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xxxii, 496 p. : 25 cm
Topics: Drug development -- History, Pharmacy -- History, Drug Discovery -- history, Pharmaceutical...
Prediction of Potential Lead Molecules through Systematic Integration of Multi-omics Datasets - A Mini-Review
Topics: Systematic Integration, Multi-omics Datasets, Drug Discovery, Lead Identification, Big Data Analysis
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Aug 27, 2014
08/14
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Stockwell, Brent R., author
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Includes bibliographical references (pages 229-249) and index
Topics: Methods, Drugs, Drug development, Proteins, Drug Design, Design, Drug Discovery, Chemistry,...
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xiii, 373 p., [24] p. of plates : 29 cm
Topics: Antiviral agents, Antiviral Agents, Drug Discovery, Viral Proteins, Virus Diseases -- drug therapy
Historically animal studies and 2D cell culture models have been strengthening biomedical and pharmaceutical research, with many limitations. Currently, new drug development for many diseases like cancer is an important necessity. An organoid is a miniaturized version of an organ produced in vitro that shows realistic micro-anatomy, is capable of self-renewal and self-organization and exhibits similar functionality as the tissue of origin. While their size is small (typically < 3 mm in...
Topics: 3D organoids, 2D cell culture, Drug discovery, Organ toxicity, High-throughput screening
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Mar 17, 2022
03/22
by
Croft, John E. (John Eric), 1932-
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127 pages, 4 unnumbered pages of plates : 23 cm
Topics: Marine pharmacology, Pharmacognosy, Aquatic Organisms -- chemistry, Drug Discovery, Biological...
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Aug 4, 2021
08/21
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Chen, Bin, 1983- author
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1 online resource (ix, 132 pages) :
Topics: Drug development, Drugs -- Research, Semantic Web, Data mining, Drug Discovery -- methods,...
Oyster mushroom Pleurotus ostreatus is belong to the group of healthy foods, as they contain high levels of proteins, vitamins and different classes of compounds, it is discovered that oyster mushrooms could play a key role in maintaining good health. Oyster mushroom Pleurotus sp. Class Basidiomycetes and Family Agaricaceae are widely known as ‘dhingri' in India. Pleurotus Ostreatus have several medicinal properties including , antitumor, immune modulatory, anti inflammatory, anticancer,...
Topics: Oyster mushroom (Pleurotus sp.), PARP Protein, 4UND Protein, Molecular Docking, PyRx, BIOVIA Drug...
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Mar 30, 2018
03/18
by
Leaf, Clifton
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Includes bibliographical references (pages 393-480) and index
Topics: Cancer, MEDICAL, Epidemiologie, Forschung, Krebs, Pharmakologie, Neoplasms, Antineoplastic Agents,...
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xiii, 363 p. :
Topics: Drugs -- Physiological transport, Carrier proteins, Membrane Transport Proteins -- Laboratory...
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Apr 7, 2021
04/21
by
Grateful Frog (gratefulfrog)
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The transmembrane domain region of the human PTHR1 was modeled (Tom Gardella) using Swiss-Model and the PDB coordinate file 4k5y of the CRFR1 as a template. The output file was rendered (GratefulFrog) using Pymol and meshlab. Watch a flyby video at: http://youtu.be/T00XZOAs7Ak
Topics: Parathyroid_hormone_receptor, PTH_Drug_Discovery, Membrane_Protein, stl, thingiverse,...
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Feb 7, 2022
02/22
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Cordes, Eugene H., author
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xiv, 243 pages : 24 cm
Topics: Drug Discovery -- history, Chemistry, Pharmaceutical -- methods, History, 20th Century, History,...
Objective: The journey of a brand-new compound from a quest laboratory followed by pilot plant production then proportion batches whereas below going through validation to a commercial product is explained under this text. A definitive objective for fruitful innovation move is to have archived proof that the fabricating measures for drug substances and medication item, individually, are hearty and successful in creating the medication substances what’s more, drug item agreeing to the enlisted...
Topics: Drug Discovery, Drug Development, Pharmaceutical Commercialization, Scale Up, Need of Technology...
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xx, 312 p. : 25 cm
Topics: Huntington's disease -- Pathophysiology, Huntington's disease -- Molecular aspects,...
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p. ; cm
Topics: Dementia -- Chemotherapy, Alzheimer Disease -- drug therapy, Alzheimer Vaccines -- economics,...
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Oct 28, 2021
10/21
by
Harrington, Peter J
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v, 369 p. : 28 cm
Topics: Pharmaceutical chemistry, Chemical processes, Chemistry, Pharmaceutical -- methods, Chemistry...
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1 online resource (253 pages) :
Topics: Biological transport, Drug targeting, Drug Discovery, Neurotransmitter Agents, MEDICAL --...
A substantial proportion of breast cancer patients develop metastases despite surgeries and adjuvant therapies. Metastasis is incurable and responsible for over 90% of breast cancer-related death. Thus, the prevention of metastasis is an imperative clinical need. We seek to understand how microscopic metastases in distant organs (e.g., bone), before becoming overt malignancies, survive and progress by interacting with specific normal cells in that organ. The rationale is that such interaction...
Topics: DTIC Archive, Zhang,Xiang, Baylor College of Medicine Houston United States, metastasis, CELLULAR...
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x, 389 p. : 26 cm
Topics: Hepatitis C -- Treatment, Antiviral agents -- Therapeutic use, Pharmaceutical biotechnology,...
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x, 290 p. : 25 cm
Topics: Receptors, G-Protein-Coupled -- chemistry, Receptors, G-Protein-Coupled -- metabolism, Drug...
17,720
18K
Sep 26, 2011
09/11
by
MITOpenCourseWare
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This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed. In addition to the regular...
Topics: sequence, structure, function, complex biological networks, quantative modeling, functional...
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Jul 23, 2018
07/18
by
Berndt, Ernst R
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xi, 236 pages : 23 cm
Topics: Vaccines industry -- United States, Market surveys -- United States, Vaccines -- economics, Drug...
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Dec 1, 2020
12/20
by
Patchett, Ann
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353 pages ; 24 cm
Topics: Scientists -- Fiction, Medicine -- Research -- Fiction, Jungles -- Amazon River Region -- Fiction,...
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xi, 376 p. : ill. ; 27cm
Topics: G proteins -- Receptors, Drug development, Receptors, G-Protein-Coupled -- Laboratory Manuals, Drug...
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xv, 510 p., [16] p. of plates : 25 cm
Topics: Protein kinases -- Inhibitors -- Therapeutic use, Antineoplastic agents, Neoplasms -- drug therapy,...
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1 online resource (xii, 501 pages) :
Topics: Drug development, Drugs -- Research, Drugs -- Design, Pharmacology, Drug Discovery, Drug Therapy,...
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1 online resource (3 volumes) :
Topics: Neuropharmacology -- methods, Animal models in research, Neuropharmacology -- Research, MEDICAL --...
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1 online resource (3 volumes) :
Topics: Neuropharmacology -- methods, Animal models in research, Neuropharmacology -- Research, MEDICAL --...
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1 online resource (3 volumes) :
Topics: Neuropharmacology -- methods, Animal models in research, Neuropharmacology -- Research, MEDICAL --...
Burger's Medicinal Chemistry & Drug Discovery Vol 2 (6th Edition) By Donald Aberham
Topics: drug, patent, erm, binding, receptor, tion, drugs, compounds, discovery, drug discovery, medicinal...
